Lekcii Po Farmakologii Dlya Med Kolledzha
• 82 Downloads • Abstract The kinetics of the initiated oxidation of a model lipid (methyl oleate has been investigated in the presence of a group of new “hybrid” structures, namely, N-substituted amides of salicylic acid whose structure contains an amide residue conjugated with, or separated by a bridging fragment (three methylene groups) from, an N-phenolic substituent. The compounds also differ in the degree of screening of the OH groups. The process was initiated by thermal decomposition of azobisisobutyronitrile at 60°C (initiation rate of w i = 4.2 × 10 −8 mol L −1 s −1) or by UV irradiation (γ = 313−365 nm, w i = 0.6 × 10 −8 mol L −1 s −1). The compounds examined exhibit antiradical activity owing to the presence of the phenolic hydroxyl groups. N-substituted salicylamides efficiently inhibit the overall methyl oleate oxidation process and are comparable in activity with dibunolum and α-tocopherol or are superior to them. The structures in which the residues of salicylamide and sterically hindered phenol are separated by the bridging fragment are particularly efficient.
The advantages of the salicylamides absorbing at 300–365 nm manifest themselves in UV-initiated oxidation. The peroxidase activity of the N-substituted salicyl acid derivatives is determined by the structure of the amide moiety. The compounds examined here are new, promising, effective antioxidants, whose particular structural fragments act via different mechanisms in oxidation.
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Contra is the second studio album by the American indie rock band Vampire Weekend, released in January 2010 on XL Recordings. It debuted at number one on the US Billboard 200. Contra was the album where Vampire Weekend discovered they could do just about anything: dubby, slo-mo gorgeousness, clattering pseudo-punk, African guitar riffs, choral swells, and even songs. Describing their sound as 'Upper West Side Soweto,' New York City's Vampire Weekend mix preppy, well-read indie rock with joyful, Afro-pop-inspired melodies and rhythms. Vampire weekend contra album rar google. Contra is the studio/Mixtape Album by artist/Rapper/DJ Vampire Weekend, and Album has highlight a Pop, Rock sound. It was released/out on 2010 in English dialect, by some Music Recording Company, as the follow-up to last studio/Mixtape Album. Best known as the musical engine behind Vampire Weekend, Rostam Batmanglij has become a go-to producer and songwriter, working with the likes of Carly Rae Jepsen and Charli XCX.